At least four teams have qualified for the quarter-final following Tuesday’s ties.
Manchester City midfielder, Phil Foden, scored twice as the Premier League champions ran riot on Bristol City 3-0.
Kevin De Bruyne rounded off the scoring with a sublime finish from 25 yards.
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A surprise, Second-tier Blackburn Rovers eliminated Leicester City in an convincing fashion beating them 2-1.
Tyrhys Dolan and Sammie Szmodics scored, before a Kelechi Iheanacho reply.
Fulham also reached the sixth round for the first time in 13 years thanks to a wonderful hit from Joao Palhinha and Manor Solomon, which earned them a 2-0 win over Leeds United.
Brighton and Hove Albion needed Evan Ferguson’s first-half goal to claim a 1-0 win over second-tier Stoke City.
The four teams are:
Manchester City
Blackburn Rovers
Fulham
Brighton and Hove Albion