The FA Cup 4th round begins with a mouth watering encounter between Manchester City and Arsenal on Friday night.
Both clubs are yet to face each other this season and will still play each other two more times before May in the EPL.
The game is the stand-out tie, as it will see the Premier League champions host the current table toppers.
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Manchester United welcome Reading to Old Trafford, while Tottenham Hotspur travel to Preston North End.
FA Cup fourth round ties:
Preston North End vs Tottenham Hotspur
Southampton vs Blackpool
Wrexham vs Sheffield United
Ipswich Town vs Burnley
Manchester United vs Reading
Luton Town vs Grimsby Town
Derby County vs West Ham United
Stoke City vs Stevenage
Blackburn Rovers vs Birmingham City
Walsall vs Leicester City
Sheffield Wednesday vs Fleetwood Town
Manchester City vs Arsenal
Bristol City vs West Bromwich Albion
Brighton & Hove Albion vs Liverpool
Fulham vs Sunderland
Accrington Stanley vs Leeds United
